GNAO1 Overexpression Promotes Neural Differentiation of Glioma Stem-Like Cells and Reduces Tumorigenicity Through TRIM21/CREB/HES1 Axis

Investigators identified G Protein Subunit Alpha O1 (GNAO1) as a critical regulator of neural differentiation of glioma stem-like cells. GNAO1 expression was lower in gliomas than in normal neuronal tissues and high expression of GNAO1 correlated with a better prognosis.