Myofibroblast-Derived Extracellular Vesicles Facilitate Cancer Stemness of Hepatocellular Carcinoma via Transferring ITGA5 to Tumor Cells

Researchers elucidated a novel mechanism by which the extracellular vesicle-mediated transfer of integrin α5 (ITGA5) from myofibroblasts to tumor cells augmented hepatocellular carcinoma (HCC) stemness. ITGA5-targeting therapy helped prevent the progression of HCC and improved the efficacy of PD-L1 treatment.