Early Disruption of the CREB Pathway Drives Dendritic Morphological Alterations in FTD/ALS Cortical Neurons

Scientists found that cortical-like neurons derived from iPSC lines carrying the hexanucleotide repeat expansion in the C9ORF72 gene, a common genetic cause of frontotemporal dementia (FTD)/ALS, displayed a diminished activation of CREB, resulting in decreased dendritic and synaptic health.