DEAD-Box RNA Helicase 10 Is Required for 18S rRNA Maturation by Controlling the Release of U3 snoRNA from Pre-rRNA in Embryonic Stem Cells

The authors discovered that DEAD-box RNA helicase 10 (DDX10) was indispensable for upholding cellular homeostasis and the viability of mouse ESCs. DDX10 participated in the process of liquid-liquid phase separation, which was necessary for efficient ribosome biogenesis.