Exacerbated Ischemic Brain Damage in Type 2 Diabetes via Methylglyoxal-Mediated miR-148a-3p Decline

Using type 2 diabetesmodels generated with streptozotocin plus a high-fat diet or db/db mice, and then inducing focal ischemic stroke through middle cerebral artery occlusion and reperfusion, scientists established a diabetic stroke mouse model.