Small-Molecule Disruption of Androgen Receptor–Dependent Chromatin Clusters

By
Emily Salmini
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0
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Scientists reported androgen receptor (AR) antagonists with efficacy in AR-overexpressing models. These molecules bound to the ligand-binding domain of the AR, promote AR localization to the nucleus, yet potently and selectively down-regulated AR-target genes.
[Proceedings of The National Academy of Sciences of The United States of America]
Abstract