Collagen Signaling and Matrix Stiffness Regulate Multipotency in Glandular Epithelial Stem Cells in Mice

Researchers found that Collagen I expression was commonly upregulated in adult basal stem cells (BaSCs) across the different multipotent conditions. Increasing collagen concentration or stiffness of the ECM promoted BaSC multipotency in mammary gland and prostate organoids.