Synergistic Anticancer Strategy Targeting ECM Stiffness: Integration of Matrix Softening and Mechanical Signal Transduction Blockade in Primary Liver Cancers

After demonstrating that ECM stiffness could affect phenotypes of primary liver cancers, researchers used intrahepatic cholangiocarcinoma to further explore the specific mechanisms underlying the impact of ECM stiffness on the progression of cancer and the effects of the application of anticancer strategies targeting ECM stiffness.