LKB1 Inactivation Promotes Epigenetic Remodeling-Induced Lineage Plasticity and Antiandrogen Resistance in Prostate Cancer

Utilizing single-cell RNA sequencing on both human and mouse prostate cancer samples, combined with whole-genome bisulfite sequencing and multiple genetically engineered mouse models, researchers investigated the molecular mechanism of androgen receptor-independent lineage plasticity and uncovered a potential therapeutic strategy.