Annexin A5 Knockdown Inhibits Cardiomyocyte Apoptosis and Alleviates Cardiac Hypertrophy via Activating the PI3K/AKT/Bcl-2 Signaling Pathway

The expression of annexin A5 (ANXA5) protein and mRNA was overexpressed, and knockdown of ANXA5 could effectively attenuate cardiomyocyte apoptosis and inflammatory response, ameliorated myocardial hypertrophy and cardiac dysfunction in ALD-induced hypertrophic cardiomyocytes and SHR hypertrophic hearts.