Tuning Surface Valences of Nanoengagers to Enhance their Structural Advantages for Efficiently Redirecting T Cells against Solid Tumors

Scientists constructed dual-specificity T cell nanoengagers (TNEs) targeting CD3 and PDL1 receptors based on a polyethylene glycol-b-polylactic acid-assembled nanoparticle and specifically studied the impact of surface antibody valences on their functional mechanisms, thereby enhancing the structural advantages of TNEs against solid tumors.