Dynamic P-Glycoprotein Expression in Early and Late Memory States of Human CD8 + T Cells and the Protective Role of Ruxolitinib

Scientists assessed which maturing human CD8+ cytotoxic T lymphocytes (CTL) memory subsets may be affected based on their P-glycoprotein (Pgp) protein expression. In an in vitro CTL differentiation model system, they tracked the maturation of naive, effector, and memory cells and the expression of Pgp.