pH-Responsive Polyethylene Glycol Engagers for Enhanced Brain Delivery of PEGylated Nanomedicine to Treat Glioblastoma

To further boost brain uptake of PEGylated nanomedicine, scientists engineered a pH-responsive anti-polyethylene glycol (PEG) × anti-transferrin receptor bispecific antibody platform, in which the pH-responsive anti-PEG arm could bind to PEG in a pH-dependent manner.