CCR5 and IL-12 Co-Expression in CAR T Cells Improves Antitumor Efficacy by Reprogramming Tumor Microenvironment in Solid Tumors

The CCL4/CCL5-CCR5 axis emerged as significantly correlated with the presence of T cells within tumors, and enhancing the expression of CCR5 in CAR T cells bolstered their migratory capacity.