Hypoxia-Inducible Factor 2 Regulates Alveolar Regeneration after Repetitive Injury in Three-Dimensional Cellular and In Vivo Models

By interrogating single-cell RNA sequencing data from patients with idiopathic pulmonary fibrosis and a mouse model of repeated lung epithelial injury, scientists identified persistent activation of hypoxia-inducible factor signaling in these aberrant epithelial cells.