XCL1-Secreting CEA CAR-T Cells Enhance Endogenous CD8+ T Cell Responses to Tumor Neoantigens to Confer a Long-Term Antitumor Immunity

Researchers modified carcinoembryonic antigen (CEA)-specific CAR-T cells, aiming to stimulate endogenous CD8+ T cell responses against neoantigens that were derived from CEA-positive tumors destroyed by the CAR T cells.