Anti-PD-1 Exacerbates Bleomycin-Induced Lung Injury in Mice via Caspase-3/GSDME-Mediated Pyroptosis

Researchers used a mouse model of lung injury induced by bleomycin (BLM) and then administered anti-programmed cell death 1 (aPD-1) antibodies to induce ICI-related lung injury. Compared with the BLM group, the aPD-1 + BLM group presented greater levels of lung inflammation and fibrosis, and decreased lung function.