Targeting the CD74 Signaling Axis Suppresses Inflammation and Rescues Defective Hematopoiesis in RUNX1-Familial Platelet Disorder

Single-cell RNA sequencing combined with functional analysis of samples from patients with RUNX1-familial platelet disorder (FPD) revealed that FPD hematopoietic stem and progenitor cells displayed increased myeloid differentiation and suppressed megakaryopoiesis because of increased activation of prosurvival and inflammatory pathways.