Modeling Early Gastrulation in Human Blastoids with DNA Methylation Patterns of Natural Blastocysts

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Researchers developed a high-fidelity blastoid model using four chemicals + leukemia inhibitory factor naive human pluripotent stem cells. By extending the 3D culture to 14 days, these blastoids mimicked early gastrulation, demonstrating the specification and migration of cells.
[Cell Stem Cell]
AbstractGraphical Abstract