FSD1 Inhibits Glioblastoma Diffuse Infiltration Through Restriction of HDAC6-Mediated Microtubule Deacetylation

Investigators increased expression of fibronectin type III and SPRY domain-containing 1 (FSD1) or interference with FSD1 phosphorylation reduces microtubule deacetylation, suppresses invasion of glioblastoma (GBM) stem cells, and ultimately mitigates tumor infiltration in orthotopic GBM xenografts.