Human Epicardial Organoids from Pluripotent Stem Cells Resemble Fetal Stage with Potential Cardiomyocyte- Transdifferentiation

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After 8-days treatment of TGF-beta following by bFGF, cells entered into epithelium-mesenchymal transition and gave rise to smooth muscle cells. Epicardium could also integrate and invade into mouse heart with SNAI1 expression, and give birth to numerous cardiomyocyte-like cells.
[Cell & Bioscience]
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