Impaired Hydrogen Sulfide Biosynthesis Underlies Eccentric Contraction-Induced Force Loss in Dystrophin-Deficient Skeletal Muscle

Investigators showed that the cysteine proteome of skeletal muscle functioned as a redox buffer in wild-type and murine dystrophin-deficient (mdx)muscle during eccentric contractions, but the buffer capacity in mdx muscle was significantly compromised by elevated basal protein oxidation.