Inhibition of Aortic CX3CR1+ Macrophages Mitigates Thoracic Aortic Aneurysm Progression in Marfan Syndrome in Mice

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Administering monoclonal antibodies to respectively neutralize TNF-α and IGF1 produced by CX3CR1+ cells from Marfan Syndrome (MFS) patients greatly suppressed the cocultured MFS patient-specific induced pluripotent stem cell-derived vascular smooth muscle cell inflammation.
[Journal of Clinical Investigation]
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