Fine-Tuning of Gene Expression through the Mettl3-Mettl14-Dnmt1 Axis Controls ESC Differentiation

0
954
Scientists demonstrated that METTL3-METTL14-dependent 5mC and m6A were both essential for the differentiation of ESCs into embryoid bodies and that the upregulation of key differentiation genes during early differentiation depended on the dynamic balance between increased 5mC and decreased m6A.
[Cell]
AbstractGraphical Abstract