CRISPR Knock-In of a Chimeric Antigen Receptor into GAPDH 3’UTR Locus Generates Potent B7H3-Specific NK-92MI Cells

Scientists established a novel type of CAR-NK cells by integrating CAR sequences into the GAPDH 3’UTR locus of NK-92MI cells, achieving site-specific integration of the CAR gene and allowing endogenous regulatory components to govern CAR expression.