CRISPR Knock-In of a Chimeric Antigen Receptor into GAPDH 3’UTR Locus Generates Potent B7H3-Specific NK-92MI Cells

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Scientists established a novel type of CAR-NK cells by integrating CAR sequences into the GAPDH 3’UTR locus of NK-92MI cells, achieving site-specific integration of the CAR gene and allowing endogenous regulatory components to govern CAR expression.
[Cancer Gene Therapy]
Abstract