A Novel USP4 Inhibitor That Suppresses Colorectal Cancer Stemness by Promoting β-Catenin and Twist1 Degradation

Investigators identified key deubiquitinating enzymes regulating CSCs and drug resistance of colorectal cancer (CRC). Gain- and loss-of-function experiments were performed to evaluate the function of USP4 in the regulation of stemness and drug sensitivity in CRC.