Insights on BMI-1 Therapeutic Targeting in Head and Neck Cancers

Current biological insights of B lymphoma Mo-MLV insertion region 1 homolog (Bmi-1_ as a master regulator of stem cell self-renewal have emerged as a prominent player in cancer stem cell biology. The authors synthesize the current knowledge on Bmi-1 with an emphasis on the role that Bmi-1 plays in oral cancer progression and evaluates how this can be used in advancing clinical treatment strategies for head and neck cancer.