Endothelial TRIM35-Regulated MMP10 Release Exacerbates Calcification of Vascular Grafts

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To test how endothelial cells interact with smooth muscle cells (SMC) in artery grafts, single-cell analysis of wild-type mice is first performed using an arterial isograft mouse model and found robust cytokine-mediated signaling pathway activation and SMC proliferation, together with upregulated endothelial tripartite motif 35 (TRIM35) expression.
[Advanced Science]
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