Combined PARP14 Inhibition and PD-1 Blockade Promotes Cytotoxic T Cell Quiescence and Modulates Macrophage Polarization in Relapsed Melanoma

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Using preclinical models and single-cell RNA sequencing, researchers investigated immune and tumor cell adaptations to poly ADP ribosyl polymerase 14 (PARP14) inhibition combined with programmed cell death 1 (PD-1) blockade.
[Journal For Immunotherapy of Cancer]
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