Suppressing APOE4-Induced Neural Pathologies by Targeting the VHL–HIF Axis

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Investigators demonstrated that targeting Caenorhabditis elegans Von Hippel–Lindau (VHL)-1 proteins could markedly suppress neural pathologies, loss of long-lasting behavioral memory, and population mortality induced by transgenic human APOE4.
[Proceedings of The National Academy of Sciences of The United States of America]
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