XOR-Derived ROS in Tie2-Lineage Cells Including Endothelial Cells Promotes Aortic Aneurysm Progression in Marfan Syndrome

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Scientists inhibited in vivo function of XOR either by endothelial cell (EC)–specific disruption of the Xdh gene or by systemic administration of an XOR inhibitor febuxostat in Marfan syndrome mice harboring the Fbn1 missense mutation p.(Cys1041Gly).
[Arteriosclerosis Thrombosis and Vascular Biology]
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