Modeling Sporadic Progressive Supranuclear Palsy in 3D Midbrain Organoids: Recapitulating Disease Features for In Vitro Diagnosis and Drug Discovery

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The midbrain organoids (MOs) were generated by pooling iPSCs from four patients with sporadic probable progressive supranuclear palsy-Richardson’s syndrome and compared them with MOs from three healthy control subjects.
[Annals of Neurology]
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