Bisdemethoxycurcumin and Curcumin Alleviate Inflammatory Bowel Disease by Maintaining Intestinal Epithelial Integrity and Regulating Gut Microbiota in Mice

Scientists assessed curcumin (CUR) and bisdemethoxycurcumin (BDMC) in a DSS-induced colitis mouse model. Dietary administration of CUR or BDMC strengthened tight junction proteins, reduced inflammatory cytokine secretion, and attenuated intestinal inflammatory protein expression, thereby alleviating DSS-induced inflammatory bowel disease in mice.