A 3D Self-Assembly Platform Integrating Decellularized Matrix Recapitulates In Vivo Tumor Phenotypes and Heterogeneity

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Researchers developed a hydrogel-free self-assembly platform to establish ECM-rich 3D “MatriSpheres” to deconvolute cancer cell-ECM interactions. MatriSpheres featured ECM-dependent transcriptional and cytokine profiles associated with malignancy, lipid metabolism, and immunoregulation.
[Cancer Research]
Abstract