A Serum- and Feeder-Free System to Generate CD4 and Regulatory T Cells from Human iPSCs

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Scientists reported a serum- and feeder-free differentiation process suitable for large-scale production. Using an optimized concentration of PMA/Ionomycin, they generated iPSC-CD4sp T cells at high efficiency and converted them to Tregs using TGFβ and ATRA.
[Stem Cells]
Abstract