ZBP1-Mediated PANoptosis Is a Crucial Lethal Form in Diverse Keratinocyte Death Modalities in UVB-Induced Skin Injury

Investigators observed that the key molecules of GSDMD-mediated pyroptosis, apoptosis, and necroptosis, which were N-terminal GSDMD, cleaved caspase-3/PARP, and phosphorylated MLKL, respectively, were elevated in keratinocytes of UVB-challenged mice and human skin tissue.