A BCL-XL/BCL-2 PROTAC Effectively Clears Senescent Cells in the Liver and Reduces MASH-Driven Hepatocellular Carcinoma in Mice

Investigators reported the finding that 753b, a dual BCL-xL/BCL-2 proteolysis-targeting chimera (PROTAC), acted as a potent and liver-tropic senolytic. Treatment with 753b selectively reduced senescent cells in the liver in aged mice.