Loss of ARID1A Accelerates Prostate Tumorigenesis with A Proliferative Collagen-Poor Phenotype through Co-Operation with AP1 Subunit CFos

Using a forward-mutagenesis sleeping Beauty transposon-based screen in a probasin Cre-recombinase Pten-deficient mouse model of prostate cancer, scientists identified Arid1a loss as a driver in the development of metastatic disease.