Transcription of Hepatitis B Surface Antigen Shifts from cccDNA to Integrated HBV DNA during Treatment

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Scientists applied a novel multiplex droplet digital PCR that identified the dominant source of hepatitis B surface antigen mRNAs to 3436 single cells from paired liver biopsies from ten people with chronic hepatitis B and HIV receiving nucleos(t)ide analogues.
[Journal of Clinical Investigation]
AbstractGraphical Abstract