Loss of SGK1 Supports Metastatic Colonization in Hepatocellular Carcinoma by Promoting Resistance to T Cell-Mediated Immunity

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Utilizing in vivo CRISPR library screening in murine HCC metastasis models under conditions of both intact and depleted T cell immunity, the authors identified genes critical to tumor immune evasion during metastatic colonization, and investigated intrinsic mechanisms.
[Journal of Hepatology]
AbstractGraphical Abstract