Histone Lactylation Promotes Multidrug Resistance in Hepatocellular Carcinoma by Forming a Positive Feedback Loop with PTEN

Scientists established oxaliplatin (OXA)- and 5-fluorouracil (5-Fu)-resistant hepatocellular carcinoma cell lines, and identified enhanced glycolytic activity in resistant cells. Inhibiting glycolysis effectively suppressed the malignant behavior of both OXA- and 5-Fu-resistant cells.