Transferrin Promotes Fatty Acid Oxidation and Liver Tumor Growth through PHD2-Mediated PPARα Hydroxylation in an Iron-Dependent Manner

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Researchers demonstrated that glucose deprivation in HCC cells induced AMPK-dependent transferrin S685 phosphorylation, which exposed transferrin nuclear localization signal for binding to importin α7 and subsequent nuclear translocation.
[Proceedings of The National Academy of Sciences of The United States of America]
Abstract