FKBP5 Inhibition Ameliorates Neurodegeneration and Motor Dysfunction in the Neuromelanin-SNCA Mouse Model of Parkinson’s Disease

To investigate the roles of neuromelanin (NM) and α-syn in dopaminergic neuron degeneration, the authors modeled Parkinson’s disease by inducing NM accumulation in a humanized α-syn mouse model via the expression of human tyrosinase in the substantia nigra.