ROS-Induced Cytosolic Release of Mitochondrial PGAM5 Promotes Colorectal Cancer Progression by Interacting with MST3

Using colorectal cancer models, investigators showed that upon sensing excessive mitochondrial reactive oxygen species, phosphatase PGAM5, which normally localizes to the mitochondria, undergoes aberrant cleavage by presenilin-associated rhomboid-like protein, becoming released into the cytoplasm.