N-Homocysteinylation of β-Arrestins Biases GPCR Signaling and Promotes Platelet Activation

By examining the effects of hyperhomocysteinemi (HHcy) on a panel of G-protein coupled receptors (GPCRs) involved in platelet aggregation, investigators found that hyperhomocysteinemia (HHcy) systematically modulated biased GPCR signaling.