LINE-1 ORF1p Mimics Viral Innate Immune Evasion Mechanisms in Pancreatic Ductal Adenocarcinoma

The authors showed that the LINE-1 ORF1 protein (ORF1p) in PDAC cells played a role in shielding repeat RNAs from activating a pathogen recognition receptor-mediated antiviral response that is independent of retrotransposition.