ARv7 Promotes the Escape of Prostate Cancer Cells from Androgen Deprivation Therapy-Induced Senescence by Mediating the SKP2/P27 Axis

Researchers demonstrated that androgen receptor (AR) splicing variant 7 (ARv7), a dominant factor mediating abnormal AR signaling and androgen deprivation therapy resistance, was closely associated with outgrowth from ADT-induced senescence of prostate cancer cells.