HBV-Associated Hepatocellular Carcinomas Inhibit Antitumor CD8⁺ T Cell via the Long Noncoding RNA HDAC2-AS2

Investigators emphasized the significance of tumor-derived extracellular vesicles in suppressing antitumor CD8+ T cell immunity to promote tumorigenesis, and highlighted extracellular HDAC2-AS2 as a promising biomarker and therapeutic target for heptaocellular carcinoma.