Heparan Sulfate Regulates Amphiregulin Programming of Tissue Reparative Lung Mesenchymal Cells During Influenza a Virus Infection in Mice

In the context of influenza A virus infection (IAV) in vivo, an Areg-responsive subset of reparative lung mesenchymal cells (LMC) upregulated glypican-4 and heparan sulfate (HS); conditional deletion of HS primarily within this LMC subset results in reduced repair characteristics following IAV infection.