Inactivation of NLRP3 Inflammasome by Dephosphorylation at Serine 658 Alleviates Glial Inflammation in the Mouse Model of Parkinson’S Disease

The virtual screening of a natural product library comprising 5,088 compounds was applied to identify five potential NLRP3 inhibitors through molecular docking scores. Then surface plasmon resonance assays were used to detect their binding affinities to the NLRP3 protein.